Time-resolved serial crystallography
CFEL2020-RF05
The candidate will extend the method of serial femtosecond crystallography using X-ray free-electron lasers and synchrotron radiation facilities to investigate the dynamics of proteins. They will investigate and apply novel mechanisms to induce dynamics in macromolecules for time-resolved measurements of these structures at room temperature or under other conditions. Novel triggers such as terahertz radiation or photo-acoustic waves will be studied on suitably prepared macromolecular nano-crystals.
The tasks of this position are to:- Develop and implement methods to induce dynamics in macromolecular crystals, in a variety of contexts
- Develop diagnostics for sensing and synchronizing triggers of dynamics in crystals
- Test and characterise such methods in crystallography experiments at synchrotron sources and XFELs
- Communicate findings in written and oral form
- A PhD in biophysics, biochemistry, structural biology, or similar
- A strong background in biophysics or biochemistry and experience in crystallography
- Experience in optical or laser-based analysis or sensing
- Self motivated and work well in an interdisciplinary team environment
- Excellent interpersonal skills and a friendly nature
- Good communication skills in English