Time-resolved serial crystallography


The candidate will extend the method of serial femtosecond crystallography using X-ray free-electron lasers and synchrotron radiation facilities to investigate the dynamics of proteins. They will investigate and apply novel mechanisms to induce dynamics in macromolecules for time-resolved measurements of these structures at room temperature or under other conditions. Novel triggers such as terahertz radiation or photo-acoustic waves will be studied on suitably prepared macromolecular nano-crystals.

The tasks of this position are to:
  • Develop and implement methods to induce dynamics in macromolecular crystals, in a variety of contexts
  • Develop diagnostics for sensing and synchronizing triggers of dynamics in crystals
  • Test and characterise such methods in crystallography experiments at synchrotron sources and XFELs
  • Communicate findings in written and oral form
The profile of the candidate:
  • A PhD in biophysics, biochemistry, structural biology, or similar
  • A strong background in biophysics or biochemistry and experience in crystallography
  • Experience in optical or laser-based analysis or sensing
  • Self motivated and work well in an interdisciplinary team environment
  • Excellent interpersonal skills and a friendly nature
  • Good communication skills in English
The position is initially limited to two years. To apply, please send mail to Prof. Henry Chapman at henry.chapman@desy.de, quoting the position CFEL2020-RF05. Please include a cover letter, CV, and list of references.