Phase retrieval for molecular imaging and crystallography


Intense coherent X-ray beams open up new opportunities for ab initio phasing of crystals to recover macromolecular images and information about the dynamics of these molecules. This project aims to develop new strategies and algorithms to extract this information, which can be present in diffuse scattering, Bragg truncation from 2D crystals and nanocrystals, or through interference caused by convergent beam illumination.

The tasks of this position are to:
  • Develop and test new approaches and algorithms to utilise coherent diffraction of macromolecular crystals for structure determination
  • Optimise diffraction experiments at synchrotron and XFEL sources for the measurement of coherent diffraction of macromolecular crystals
  • Develop and test new experimental methods to acquire novel diffraction data from macromolecular crystals and other systems
  • Contribute to execution, analysis and developments of imaging experiments of the group
  • Communicate findings in written and oral form
The profile of the candidate:
  • A PhD in physics, materials science, optics, or similar
  • A strong background and knowledge of diffraction physics, data analysis, crystallography, or modern microscopy methods (such as ptychography)
  • Self motivated and work well in an interdisciplinary team environment
  • Excellent interpersonal skills and a friendly nature
  • Good communication skills in English
The position is initially limited to two years. To apply, please send mail to Prof. Henry Chapman at, quoting the position CFEL2020-RF02. Please include a cover letter, CV, and list of references.